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1bqy
From Proteopedia
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:56:47 2007'' |
Revision as of 12:52, 30 October 2007
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PLASMINOGEN ACTIVATOR (TSV-PA) FROM SNAKE VENOM
Overview
BACKGROUND: Trimeresurus stejnejeri venom plasminogen activator (TSV-PA), is a snake venom serine proteinase that specifically activates, plasminogen. Snake venom serine proteinases form a subfamily of, trypsin-like proteinases that are characterised by a high substrate, specificity and resistance to inhibition. Many of these venom enzymes, specifically interfere with haemostatic mechanisms and display a long, circulating half-life. For these reasons several of them have commercial, applications and are potentially attractive pharmacological tools., RESULTS: The crystal structure of TSV-PA has been determined to 2.5 A, resolution and refined to an R factor of 17.8 (R free, 24.4). The enzyme, showing the overall polypeptide fold of trypsin-like serine proteinases, displays unique ... [(full description)]
About this Structure
1BQY is a [Single protein] structure of sequence from [Viridovipera stejnegeri]. Structure known Active Site: . Full crystallographic information is available from [OCA].
Reference
The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases., Parry MA, Jacob U, Huber R, Wisner A, Bon C, Bode W, Structure. 1998 Sep 15;6(9):1195-206. PMID:9753698
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