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1qmc
From Proteopedia
(New page: 200px<br /> <applet load="1qmc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qmc" /> '''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTE...) |
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| - | [[Image:1qmc.gif|left|200px]]<br /> | + | [[Image:1qmc.gif|left|200px]]<br /><applet load="1qmc" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1qmc" size=" | + | |
caption="1qmc" /> | caption="1qmc" /> | ||
'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES'''<br /> | '''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the C-terminal DNA-binding domain of human immunovirus-1 | + | The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564. |
==About this Structure== | ==About this Structure== | ||
| - | 1QMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http:// | + | 1QMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Boelens, R.]] | [[Category: Boelens, R.]] | ||
| - | [[Category: Eijkelenboom, A | + | [[Category: Eijkelenboom, A P.A M.]] |
[[Category: Hard, K.]] | [[Category: Hard, K.]] | ||
[[Category: Kaptein, R.]] | [[Category: Kaptein, R.]] | ||
| - | [[Category: Lutzke, R | + | [[Category: Lutzke, R A.Puras.]] |
| - | [[Category: Plasterk, R | + | [[Category: Plasterk, R H.A.]] |
[[Category: Sprangers, R.]] | [[Category: Sprangers, R.]] | ||
[[Category: aids]] | [[Category: aids]] | ||
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[[Category: src homology 3 (sh3)-like fold]] | [[Category: src homology 3 (sh3)-like fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:41:15 2008'' |
Revision as of 12:41, 21 February 2008
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C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES
Overview
The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564.
About this Structure
1QMC is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096
Page seeded by OCA on Thu Feb 21 14:41:15 2008
