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Template:STRUCTURE 1h8f

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{{StructureD
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{{Structure
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|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|1h8f, resolution 2.80&Aring; (<scene name='initialview01'>initial scene</scene>)}}}
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|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1h8f]], [[Resolution|resolution]] 2.80&Aring; (<scene name='initialview01'>default scene</scene>)}}}
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|SITE= <scene name='pdbsite=AC1:Epe+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>
|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00220 S_TKc]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8f RCSB], [http://www.ebi.ac.uk/pdbsum/1h8f PDBsum]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8f OCA], [http://www.ebi.ac.uk/pdbsum/1h8f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h8f RCSB]</span>
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|FUNCTION={{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0002039 | text = p53 binding}}{{GO|id=GO:0051059 | text = NF-kappaB binding}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0004674 | text = protein serine/threonine kinase activity}}{{GO|id=GO:0004672 | text = protein kinase activity}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0004696 | text = glycogen synthase kinase 3 activity}}
|FUNCTION={{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0002039 | text = p53 binding}}{{GO|id=GO:0051059 | text = NF-kappaB binding}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0004674 | text = protein serine/threonine kinase activity}}{{GO|id=GO:0004672 | text = protein kinase activity}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0004696 | text = glycogen synthase kinase 3 activity}}
|PROCESS={{GO|id=GO:0046827 | text = positive regulation of protein export from nucleus}}{{GO|id=GO:0018105 | text = peptidyl-serine phosphorylation}}{{GO|id=GO:0060070 | text = Wnt receptor signaling pathway through beta-catenin}}{{GO|id=GO:0006983 | text = ER overload response}}{{GO|id=GO:0016055 | text = Wnt receptor signaling pathway}}{{GO|id=GO:0043066 | text = negative regulation of apoptosis}}{{GO|id=GO:0006468 | text = protein amino acid phosphorylation}}{{GO|id=GO:0007242 | text = intracellular signaling cascade}}{{GO|id=GO:0005977 | text = glycogen metabolic process}}
|PROCESS={{GO|id=GO:0046827 | text = positive regulation of protein export from nucleus}}{{GO|id=GO:0018105 | text = peptidyl-serine phosphorylation}}{{GO|id=GO:0060070 | text = Wnt receptor signaling pathway through beta-catenin}}{{GO|id=GO:0006983 | text = ER overload response}}{{GO|id=GO:0016055 | text = Wnt receptor signaling pathway}}{{GO|id=GO:0043066 | text = negative regulation of apoptosis}}{{GO|id=GO:0006468 | text = protein amino acid phosphorylation}}{{GO|id=GO:0007242 | text = intracellular signaling cascade}}{{GO|id=GO:0005977 | text = glycogen metabolic process}}
|COMPONENT={{GO|id=GO:0005737 | text = cytoplasm}}{{GO|id=GO:0005634 | text = nucleus}}{{GO|id=GO:0030877 | text = beta-catenin destruction complex}}
|COMPONENT={{GO|id=GO:0005737 | text = cytoplasm}}{{GO|id=GO:0005634 | text = nucleus}}{{GO|id=GO:0030877 | text = beta-catenin destruction complex}}
|SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fA02 1H8Fa02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fA01 1H8Fa01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fB02 1H8Fb02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fB01 1H8Fb01]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011009 Ipr011009], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000719 Ipr000719], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR008271 Ipr008271], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002290 Ipr002290]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00069 PF00069]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=65733 d1h8fa_], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=65734 d1h8fb_]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P49841 P49841]</span>
|SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fA02 1H8Fa02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fA01 1H8Fa01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fB02 1H8Fb02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1h8fB01 1H8Fb01]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011009 Ipr011009], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000719 Ipr000719], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR008271 Ipr008271], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002290 Ipr002290]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00069 PF00069]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=65733 d1h8fa_], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=65734 d1h8fb_]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P49841 P49841]</span>
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|FARESOURCES=<span class='plainlinks'>GeneCard : [http://www.genecards.org/cgi-bin/carddisp.pl?id=P49841 P49841]</span>
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|uPDB=1H8F|CONSURF={{!}}-
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{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
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{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
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{{!}} '''Toggle Conservation Colors:'''
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{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
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}}
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Current revision

Drag the structure with the mouse to rotate
1h8f, resolution 2.80Å ()
Ligands:
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


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