Glutathione S-transferase

From Proteopedia

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Revision as of 09:57, 19 December 2012

Glutathione S-transferase (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal.

GST

4hz4 – GST – Actinobacillus pleuropneumoniae
1gsb, 1gsc – rGST – rat
3ubk – LiGST – Leptospira interrogans
3uap - GST – Methylococcus capsulatus
1aw9 - cGST III – corn
1okt – PfGST – Plasmodium falciparum
3fr6 - PfGST (mutant)
1tw9 – GST - Heligmosomoides polygyrus
1yq1 - CeGST – Caenorhabditis elegans
1y6e - SjGST – Schistosoma japonicum
2fno, 3lq7 - AtGST – Agrobacterium tumefaciens
2on7 – NaGST-1 – Necator americanus
3erf - yGST II – yeast
3f6f – DmGST – Drosophila melanogaster
3lxt - PsfGST – Pseudomonas fluorescens
4eci - PaGST – Pseudomonas aeruginosa
3niv - GST – Legionella pneumophila
3tot - RsGST – Ralstonia solanacearum
3ay8 - siGST – silkworm
1jlw - AcGST - Anopheles cracens
4f03 - PcGST - Phanerochaete chrysosporium

GST binary complex with GSH

2x64 – GST + GSH – Xylella fastidiosa
4hz2 - GST + GSH - Xanthobacter autotrophicus
4ecj - PaGST + GSH
1fhe, 2fhe - FhGST + GSH – Fasciola hepatica
1pmt, 2pmt - GST + GSH – Proteus mirabilis
1m0u, 3gh6 - DmGST + GSH
1oe7, 1oe8 - ShGST + GSH – Schistosoma haematobium
1u3i - GST + GSH - Schistosoma mansoni
1oyj - GST + GSH - rice
1u87, 1gne - SjGST + GSH
2dsa, 2gdr - GST + GSH – Burkholderia xenovorans
2on5 – NaGST-2 + GSH
2nto - OaGST + GSH – Ochrobactrum anthropi
2pvq - OaGST (mutant) + GSH
3ibh - yGST II + GSH
3fr9 - PfGST + GSH
3m3m - PsfGST + GSH
3lsz - GST + GSH – Rhodobacter sphaeroides
3n5o - GST + GSH – Coccidioides immitis
3tou - RsGST + GSH
3uar - McGST + GSH
4g9h, 4gci - GST + GSH – Yersinia pestis
4gf0 - GST + GSH - Sulfitobacter
1jlv - AcGST + GSH
4g19 - PcGST + GSH

GST binary complex

3ubl - LiGST + GSH derivative
2gsq – sqGST + GSH derivative – squid
2gst, 3gst, 4gst, 5gst, 1gss - rGST + GSH derivative
1gnw - AtGST + GSH derivative – Arabidopsis thaliana
1aqv - hGST + GSH derivative – human
1gtb, 1gta - SjGST + praziquantel
1m99, 1m9a, 1m9b - SjGST + GSH derivative
1q4j, 2aaw, 3frc - PfGST + GSH derivative
3fr3 - PfGST (mutant) + GSH derivative
1bx9 - AtGST + herbicide
1bye - cGST I + herbicide
1axd – cGST I + lactoyl-GSH
1a0f, 1n2a - GST + GSH derivative – Eschericia coli
1f2e - GST + GSH derivative – Sphingomonas paucimobilis
1mtc - rGST + GSH derivative
1ua5 - SjGST + GSH derivative
1u88 - SjGST (mutant) + GSH derivative
3erg - yGST II + GSH derivative
3qmz - yGST + dynein heavy chain
2ycd - AtGST + GSH derivative

GST α class

1guh, 1gsd, 1k3o, 1pkz – hGST A1-1
1xwg, 3q74, 3u6v, 3zfb, 3zfl - hGST A1-1 (mutant)
1gum - hGST A4-4
1guk - mGST A4-4 – mouse
1vf4 - GgGST A1-1 - chicken

GST α class complex with GSH

1pkw - hGST + GSH
1usb - hGST (mutant) + GSH
1f3a - mGST A1-1+ GSH
3i69, 3i6a - hGST A1-1 (mutant)+ GSH
2wju - hGST A2-2 + GSH
4acs - hGST A2-2 (mutant) + GSH
1tdi - hGST A3-3 + GSH
1vf1 - GgGST A1-1 + GSH

GST α class complex

1gsf – hGST A1-1 + ethacrynic acid
1ags, 1pl2, 1ydk, 2r3x, 2r6k, 3ktl, 3l0h – hGST (mutant) + GSH derivative
1k3l, 1k3y, 1pl1 - hGST + GSH derivative
1gse – hGST (mutant) + GSH + ethacrynic acid
3ik9 - hGST A1-1 + GSDN
2vct - hGST A2-2 + steroid
2vcv - hGST A3-3 + steroid
1gul - hGST A4-4+ iodobenzyl-GSH
3ik7 - hGST A4-4 + GSDHN
1b48 - mGST A4-4 + GSH derivative
1f3b - mGST A1-1 + GSH derivative
1ml6 - mGST A2-2+ GSH derivative
1ev4, 1ev9 - rGST A1-1 (mutant) + GSH derivative
1vf2, 1vf3 – GgGST A1-1 + GSH derivative

GST δ class

1r5a, 1v2a, 1pn9 - AcGST + GSH derivative
3f63, 3g7i - AdGST + GSH derivative - Anopheles dirus
3f6d, 3g7j - AdGST )mutant) + GSH derivative
3ein - DmGST + GSH
3vk9 - siGST

GST ε class

2il3 - AgGST – Anopheles gambiae
2imi - AgGST + GSH
2imk - AgGST + GSH derivative

GST κ class

3rpp - hGST
1r4w - rGST + GSH derivative
1yzx, 3rpn - hGST + GSH derivative

GST μ class

1gsb, 1gsc – rGST
6gsu, 6gsv, 6gsw, 6gsx, 6gsy, 5fwg, 3fyg - rGST (mutant)
1gtu, 2gtu, 3gtu, 4gtu - hGST
2dc5 - mGST
2wrt - FhGST

GST μ class complex with GSH

1xw5, 1xw6 - hGST + GSH
2f8f - mGST (mutant) + GSH
3crt - SjGST + GSH
3cru, 3d0z - SjGST (mutant) + GSH
6gst - rGST + GSH

GST μ class complex

1gst - GgGST + GSH derivative
1c72 - GgGST + conjugate
1hna, 1hnb, 1hnc, 1xwk, 1ykc, 1yj6, 2ab6, 2f3m – hGST + GSH derivative
2c4j - hGST (mutant) + GSH derivative
1b4p - rGST + GSH derivative
3gur - hGST + GSH + drug
3gus - hGST + drug
1gsu - cGST + GSH derivative

GST ν class

2ws2 - GST – Haemonchus contortus

GST π class

1bay - mGST
10gs, 14gs, 16gs, 1lbk - hGST
22gs, 1eog, 1eoh, 3hjm, 3hkr, 3kmn - hGST (mutant)

GST π class complex with GSH

1gsy - mGST + GSH
1tu7, 2hnl - OvGST + GSH - Onchocerca volvulus
5gss, 6gss, 7gss, 8gss, 19gs, 3dd3 - hGST + GSH
1md3, 1md4, 1px6, 1px7, 1kbn - hGST (mutant) + GSH
3t2u - GST + GSH – Wuchereria bancrofti

GST π class complex

1gss – rGST + GSH derivative
1tu8 - OvGST + GSH derivative
1glq, 1glp, 2glr, 1gti - mGST + GSH derivative
2oac, 2oad, 2oa7, 3o76 - mGST (mutant) + GSH derivative
2gss, 3dgq – hGST + ethacrynic acid
3n9j - hGST + ethacrynic acid derivative
3gss, 11gs – hGST + ethacrynic acid + GSH
3hjo, 3km6, 3kmo - hGST (mutant) + ethacrynic acid + GSH
1pgt, 2pgt, 4gss, 17gs, 2j9h, 3csi - hGST (mutant) + GSH derivative
1aqw, 1aqx, 9gss, 12gs, 18gs, 3pgt, 4pgt, 1zgn, 2a2r, 2a2s, 3csh - hGST + GSH derivative
20gs - hGST + cibacron blue
13gs, 3csj - hGST + drug
3ie3 - hGST (mutant) + drug
2gsr - GST + GSH derivative - pig

GST ρ class

3qav - AcGST – Atlantic clam
3qaw - AcGST + GSH

GST σ class

2c8u, 2cai - ShGST (mutant)
2ca8 - ShGST + GSH
2wb9 - FhGST + GSH
2wdu - FhGST + GSH + GSH derivative
1zl9 - CeGST + GSH
4ec0, 4edz, 4ee0, 4edy, 1iyh, 1iyi, 2vcq, 2vcw, 2vcx, 2vcz, 2vd0, 2vd1 - hGST + GSH
3vi7 - hGST (mutant) + GSH
1v40, 2cvd, 3ee2, 3kxo - hGST + GSH + inhibitor
3vi5, 3vi7 - hGST (mutant) + GSH + inhibitor
2caq - ShGST (mutant) + GSH
1pd2 - rGST + GSH
2c80 - ShGST + GSH derivative
1gsq - sqGST + GSH derivative

GST ϑ class

2ljr, 2c3n - hGST
2c3t - hGST (mutant)
1ljr - hGST + GSH
3mak - DmGST + GSH
3ljr - hGST + GSH derivative
2c3q - hGST (mutant) + GSH derivative

GST χ class

3ppu - PcGST + GSH

GST ω class

1eem – hGST
3q18, 3vln - hGST (mutant)
3rbt - siGST
3lfl - hGST + GSH
3qag, 3q19 - hGST (mutant) + GSH

GST ζ class

1e6b – AtGST
2cz3 - mGST
2cz2 - mGST + GSH
1fw1 - hGST + GSH

GST τ class

1gwc - GST – wheat
2vo4 - sGST + GSH derivative – soybean
3fhs - sGST + GSH

Microsomal GST

2h8a - rGST + GSH

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Glutathione_S-transferase"

@@ Line 24: / Line 24: @@
 [[3tot]] - RsGST – ''Ralstonia solanacearum''<br />
 [[3ay8]] - siGST – silkworm<br />
+[[1jlw]] - AcGST - ''Anopheles cracens''<br />
+[[4f03]] - PcGST - ''Phanerochaete chrysosporium''
 ===GST binary complex with GSH===
@@ Line 30: / Line 32: @@
 [[4hz2]] - GST + GSH - ''Xanthobacter autotrophicus''<br />
 [[4ecj]] - PaGST + GSH<BR />
-[[1fhe]], [[2fhe]] - GST + GSH – ''Fasciola hepatica''<br />
+[[1fhe]], [[2fhe]] - FhGST + GSH – ''Fasciola hepatica''<br />
 [[1pmt]], [[2pmt]] - GST + GSH – ''Proteus mirabilis''<br />
 [[1m0u]], [[3gh6]] - DmGST + GSH<BR />
@@ Line 36: / Line 38: @@
 [[1u3i]] - GST + GSH - ''Schistosoma mansoni''<br />
 [[1oyj]] - GST + GSH - rice<br />
-[[1u87]] - SjGST + GSH<BR />
+[[1u87]], [[1gne]] - SjGST + GSH<BR />
 [[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br />
 [[2on5]] – NaGST-2 + GSH<BR />
@@ Line 49: / Line 51: @@
 [[3uar]] - McGST + GSH<BR />
 [[4g9h]], [[4gci]] - GST + GSH – ''Yersinia pestis''<br />
-[[4gf0]] - GST + GSH - ''Sulfitobacter''
+[[4gf0]] - GST + GSH - ''Sulfitobacter''<br />
+[[1jlv]] - AcGST + GSH<br />
+[[4g19]] - PcGST + GSH
 ===GST binary complex===
 [[3ubl]] - LiGST + GSH derivative<br />
-[[2gsq]] – GST + GSH derivative – squid<br />
+[[2gsq]] – sqGST + GSH derivative – squid<br />
 [[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]] - rGST + GSH derivative<br />
 [[1gnw]] - AtGST + GSH derivative – ''Arabidopsis thaliana'' <br />
@@ Line 77: / Line 81: @@
 [[1guh]], [[1gsd]], [[1k3o]], [[1pkz]] – hGST A1-1<br />
-[[1xwg]], [[3q74]], [[3u6v]] - hGST A1-1 (mutant) <br />
+[[1xwg]], [[3q74]], [[3u6v]], [[3zfb]], [[3zfl]] - hGST A1-1 (mutant) <br />
 [[1gum]] - hGST A4-4<br />
 [[1guk]] - mGST A4-4 – mouse<br />
@@ Line 112: / Line 116: @@
 ===GST δ class===
-[[1r5a]], [[1v2a]], [[1pn9]] - GST + GSH derivative - ''Anopheles cracens''<br />
+[[1r5a]], [[1v2a]], [[1pn9]] - AcGST + GSH derivative <br />
+[[3f63]], [[3g7i]] - AdGST + GSH derivative - ''Anopheles dirus''<br />
+[[3f6d]], [[3g7j]] - AdGST )mutant) + GSH derivative<br />
 [[3ein]] - DmGST + GSH<BR />
 [[3vk9]] - siGST
@@ Line 134: / Line 140: @@
 [[1gtu]], [[2gtu]], [[3gtu]], [[4gtu]] - hGST<br />
 [[2dc5]] - mGST <br />
-[[2wrt]] - GST – Fasciola hepatica
+[[2wrt]] - FhGST
 ===GST μ class complex with GSH===
@@ Line 142: / Line 148: @@
 [[3crt]] - SjGST + GSH<BR />
 [[3cru]], [[3d0z]] - SjGST (mutant) + GSH<BR />
+[[6gst]] - rGST + GSH
 ===GST μ class complex===
@@ Line 151: / Line 158: @@
 [[1b4p]] - rGST + GSH derivative<br />
 [[3gur]] - hGST + GSH + drug<br />
-[[3gus]] - hGST + drug
+[[3gus]] - hGST + drug<br />
+[[1gsu]] - cGST + GSH derivative
 ===GST ν class===
@@ Line 185: / Line 193: @@
 [[20gs]] - hGST + cibacron blue<br />
 [[13gs]], [[3csj]] - hGST + drug<br />
-[[3ie3]] - hGST (mutant) + drug
+[[3ie3]] - hGST (mutant) + drug<br />
+[[2gsr]] - GST + GSH derivative - pig
 ===GST ρ class===
@@ Line 195: / Line 204: @@
 [[2c8u]], [[2cai]] - ShGST (mutant) <br />
 [[2ca8]] - ShGST + GSH<BR />
+[[2wb9]] - FhGST + GSH<br />
+[[2wdu]] - FhGST + GSH + GSH derivative<br />
 [[1zl9]] - CeGST + GSH<BR />
 [[4ec0]], [[4edz]], [[4ee0]], [[4edy]], [[1iyh]], [[1iyi]], [[2vcq]], [[2vcw]], [[2vcx]], [[2vcz]], [[2vd0]], [[2vd1]] - hGST + GSH<BR />
@@ Line 204: / Line 215: @@
 [[1pd2]] - rGST + GSH<BR />
 [[2c80]] - ShGST + GSH derivative<br />
+[[1gsq]] - sqGST + GSH derivative
 ===GST ϑ class===
@@ Line 216: / Line 228: @@
 ===GST χ class===
-[[3ppu]] - GST + GSH – ''Phanerochaete  chrysosporium''
+[[3ppu]] - PcGST + GSH
 ===GST ω class===
@@ Line 231: / Line 243: @@
 [[2cz3]] - mGST <br />
 [[2cz2]] - mGST + GSH<BR />
+[[1fw1]] - hGST + GSH
 ===GST τ class===