1srs
From Proteopedia
(New page: 200px<br /> <applet load="1srs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1srs, resolution 3.200Å" /> '''SERUM RESPONSE FAC...) |
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| - | [[Image:1srs.gif|left|200px]]<br /> | + | [[Image:1srs.gif|left|200px]]<br /><applet load="1srs" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1srs" size=" | + | |
caption="1srs, resolution 3.200Å" /> | caption="1srs, resolution 3.200Å" /> | ||
'''SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA'''<br /> | '''SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The human serum response factor is a transcription factor belonging to the | + | The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1SRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Pellegrini, L.]] | [[Category: Pellegrini, L.]] | ||
| - | [[Category: Richmond, T | + | [[Category: Richmond, T J.]] |
[[Category: Tan, S.]] | [[Category: Tan, S.]] | ||
[[Category: complex (dna binding protein/dna)]] | [[Category: complex (dna binding protein/dna)]] | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:34 2008'' |
Revision as of 13:04, 21 February 2008
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SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA
Contents |
Overview
The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.
Disease
Known disease associated with this structure: Osteoarthritis of hip, female-specific, susceptibility to OMIM:[605083]
About this Structure
1SRS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of serum response factor core bound to DNA., Pellegrini L, Tan S, Richmond TJ, Nature. 1995 Aug 10;376(6540):490-8. PMID:7637780
Page seeded by OCA on Thu Feb 21 15:04:34 2008
