D-xylose isomerase

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	[[3qza]] - SrDXI - neutron		[[3qza]] - SrDXI - neutron
-	===Mn-containing DXI===	+	==Mn-containing DXI==
	[[1xis]], [[1xib]], [[1xij]], [[2glk]], [[3n4a]] – SrDXI + Mn<br />		[[1xis]], [[1xib]], [[1xij]], [[2glk]], [[3n4a]] – SrDXI + Mn<br />

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Revision as of 12:59, 24 December 2012

Template:STRUCTURE 4xis

D-xylose isomerase (DXI) catalyzes the conversion of D-xylose (DX) to D-xylitol. DXI is part of the fructose and mannose metabolism pathways and is used commercially in the production of corn syrup. Sorbitol is a competitive inhibitor of DXI. DXI is a metal-ion activated tetramer.

Contents 1 3D structures of D-xylose isomerase 2 Mn-containing DXI 3 Mn-containing DXI complex 3.1 Mg-containing DXI 4 Mg-containing DXI complex 4.1 Co-containing DXI 5 Co-containing DXI complex 5.1 Al-containing DXI 5.2 Zn-containing DXI 5.3 Cd-containing DXI 5.4 Ni-containing DXI 5.5 Ca-containing DXI 5.6 Bi-metal-containing DXI

3D structures of D-xylose isomerase

6xia – DXI – Streptomyces albus
1xla – ArDXI – Arthrobacter
3xin, 7xim - AmDXI - Actinoplanes missouriensis
1bhw - AmDXI (mutant)
1bxb, 1bxc - DXI – Thermus thermophilus
2gub, 3kbj, 3kcj – SrDXI - Streptomyces rubiginosus
3qza - SrDXI - neutron

Mn-containing DXI

1xis, 1xib, 1xij, 2glk, 3n4a – SrDXI + Mn
2gyi - SoDXI + Mn – Streptomyces olivochromogenos
1xle, 1xlk - ArDXI + Mn
1a0d - DXI + Mn – Bacillus stearothermophilus

Mn-containing DXI complex

4xis, 1xic - SrDXI + DX + Mn
1xld, 1xlj - ArDXI + xylitol + Mn
1xig, 3gnx - SrDXI + xylitol + Mn
1s5n - SoDXI + xylitol + Mn
1xii - SrDXI + xylulose + Mn
8xia – SrDXI + DX + Mn
9xia – SrDXI + fructose + Mn
1xif - SrDXI + glucose + Mn
1s5m - SoDXI + glucose + Mn
1xid - SrDXI + ascorbate + Mn
1xie, 1xih - SrDXI + sorbitol + Mn
1did - ArDXI + glucitol + Mn
1xlf - ArDXI + gluconic acid + Mn
1xli - ArDXI + glucose derivative + Mn

Mg-containing DXI

1xlb - ArDXI + Mg
1xya, 1xyl - SoDXI + Mg
3u3h - SrDXI + Mg

Mg-containing DXI complex

1xyb, 1xym - SoDXI + glucose + Mg
1xyc - SoDXI + fructose + Mg
4xia, 5xim – ArDXI + sorbitol + Mg
5xia, 1xlc, 1xlg – ArDXI + xylitol + Mg
2xis, 4duo - SrDXI + xylitol + Mg
3cwh - SrDXI + xylulose + Mg
2xim, 1xin - AmDXI + xylitol + Mg
5xin, 6xim, 8xim, 9xim - AmDXI + DX + Mg
3xis - SrDXI + DX + Mg
1die - ArDXI + moranoline + Mg

Co-containing DXI

4xim - AmDXI + Co
2a0c - DXI + Co – Thermoanaerobacterium
1a0e - DXI + Co – Thermotoga neapolitana
1qt1 - SdDXI + Co – Streptomyces diastaticus
2gve, 4a8i, 4a8l, 4a8r, 4a8n - SrDXI + Co

Co-containing DXI complex

1xim - AmDXI + xylitol + Co
3xim, 2xin - AmDXI + sorbitol + Co

Al-containing DXI

1xlh - ArDXI + Al
1xlm - ArDXI (mutant) + xylitol + Al

Zn-containing DXI

1xll - ArDXI + Zn

Cd-containing DXI

3kbs - SrDXI + Cd
3kbm, 3kcl - SrDXI + glucose + Cd

Ni-containing DXI

3kbv, 3qys - SrDXI + Ni
3kbn, 3kco - SrDXI + glucose + Ni
4dvo - SrDXI + sorbitol + Ni

Ca-containing DXI

1gw9 - SrDXI + DX + Ca

Bi-metal-containing DXI

1mnz, 1o1h, 2g4j - SrDXI + Mg + Ca
1oad, 4e3v - SrDXI + Mg + Mn
1muw - SoDXI + Mg + Mn
1clk - SdDXI + Co + Mg
3kbw - SrDXI + Ni + Mg