This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1gkz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 28: Line 28:
[[Category: potassium]]
[[Category: potassium]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:24:43 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:14:36 2007''

Revision as of 13:09, 30 October 2007

Image:1gkz.gif

1gkz, resolution 2.20Å

Drag the structure with the mouse to rotate

BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE (BCK) COMPLXED WITH ADP

Overview

Mitochondrial protein kinases (mPKs) are molecular switches that, down-regulate the oxidation of branched-chain alpha-ketoacids and, pyruvate. Elevated levels of these metabolites are implicated in disease, states such as insulin-resistant Type II diabetes, branched-chain, ketoaciduria, and primary lactic acidosis. We report a three-dimensional, structure of a member of the mPK family, rat branched-chain alpha-ketoacid, dehydrogenase kinase (BCK). BCK features a characteristic, nucleotide-binding domain and a four-helix bundle domain. These two, domains are reminiscent of modules found in protein histidine kinases, (PHKs), which are involved in two-component signal transduction systems., Unlike PHKs, BCK dimerizes through direct interaction of two opposing, nucleotide-binding domains. ... [(full description)]

About this Structure

1GKZ is a [Single protein] structure of sequence from [Rattus norvegicus] with MG, K, CL, XE and ADP as [ligands]. Active as [Transferred entry: 2.7.11.4], with EC number [2.7.1.115]. Structure known Active Site: K. Full crystallographic information is available from [OCA].

Reference

Structure of rat BCKD kinase: nucleotide-induced domain communication in a mitochondrial protein kinase., Machius M, Chuang JL, Wynn RM, Tomchick DR, Chuang DT, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11218-23. Epub 2001 Sep 18. PMID:11562470

Page seeded by OCA on Tue Oct 30 15:14:36 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gkz"
Personal tools