1glo
From Proteopedia
| Line 28: | Line 28: | ||
[[Category: thiol proteas]] | [[Category: thiol proteas]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:14:50 2007'' |
Revision as of 13:10, 30 October 2007
|
CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S
Overview
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain, superfamily, plays a critical role in the generation of a major, histocompatibility complex (MHC) class II restricted T-cell response by, antigen-presenting cells. Therefore, selective inhibition of this enzyme, may be useful in modulating class II restricted T-cell responses in, immune-related disorders such as rheumatoid arthritis, multiple sclerosis, and extrinsic asthma. The three-dimensional structure at 2.2 A resolution, of the active-site Cys25-->Ser mutant presented here in an unliganded, state provides further insight useful for the design of selective enzyme, inhibitors.
About this Structure
1GLO is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Cathepsin S], with EC number [3.4.22.27]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830
Page seeded by OCA on Tue Oct 30 15:14:50 2007
