1ukl
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear | + | The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through a direct interaction of its helix-loop-helix leucine zipper domain with importin-beta. We show the crystal structure of importin-beta complexed with the active form of SREBP-2. Importin-beta uses characteristic long helices like a pair of chopsticks to interact with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a pseudo-twofold symmetry on its surface structure so that it can accommodate a symmetric dimer molecule. Importin-beta may use a similar strategy to recognize other dimeric cargoes. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Imamoto, N.]] | [[Category: Imamoto, N.]] | ||
| - | [[Category: Lee, S | + | [[Category: Lee, S J.]] |
[[Category: Nagoshi, E.]] | [[Category: Nagoshi, E.]] | ||
[[Category: Nakagawa, A.]] | [[Category: Nakagawa, A.]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:25:31 2008'' |
Revision as of 13:25, 21 February 2008
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Crystal structure of Importin-beta and SREBP-2 complex
Overview
The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through a direct interaction of its helix-loop-helix leucine zipper domain with importin-beta. We show the crystal structure of importin-beta complexed with the active form of SREBP-2. Importin-beta uses characteristic long helices like a pair of chopsticks to interact with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a pseudo-twofold symmetry on its surface structure so that it can accommodate a symmetric dimer molecule. Importin-beta may use a similar strategy to recognize other dimeric cargoes.
About this Structure
1UKL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor., Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y, Science. 2003 Nov 28;302(5650):1571-5. PMID:14645851
Page seeded by OCA on Thu Feb 21 15:25:31 2008
