1v1j
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The fluoro analogue of the enolate intermediate in the reaction catalyzed | + | The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces coelicolor]] | [[Category: Streptomyces coelicolor]] | ||
| - | [[Category: Coggins, J | + | [[Category: Coggins, J R.]] |
| - | [[Category: Lapthorn, A | + | [[Category: Lapthorn, A J.]] |
| - | [[Category: Roszak, A | + | [[Category: Roszak, A W.]] |
[[Category: FA3]] | [[Category: FA3]] | ||
[[Category: TRS]] | [[Category: TRS]] | ||
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[[Category: shikimate]] | [[Category: shikimate]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:30:35 2008'' |
Revision as of 13:30, 21 February 2008
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CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO
Overview
The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.
About this Structure
1V1J is a Single protein structure of sequence from Streptomyces coelicolor with and as ligands. Active as 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210
Page seeded by OCA on Thu Feb 21 15:30:35 2008
