1gv4

From Proteopedia

Revision as of 13:15, 30 October 2007

MURINE APOPTOSIS-INDUCING FACTOR (AIF)

Overview

Mitochondria play a key role in apoptosis due to their capacity to release, potentially lethal proteins. One of these latent death factors is, cytochrome c, which can stimulate the proteolytic activation of caspase, zymogens. Another important protein is apoptosis-inducing factor (AIF), a, flavoprotein that can stimulate a caspase-independent cell-death pathway, required for early embryonic morphogenesis. Here, we report the crystal, structure of mouse AIF at 2.0 A. Its active site structure and redox, properties suggest that AIF functions as an electron transferase with a, mechanism similar to that of the bacterial ferredoxin reductases, its, closest evolutionary homologs. However, AIF structurally differs from, these proteins in some essential features, including a long insertion in a, ... [(full description)]

About this Structure

1GV4 is a [Single protein] structure of sequence from [Mus musculus] with FAD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

The crystal structure of the mouse apoptosis-inducing factor AIF., Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, Nat Struct Biol. 2002 Jun;9(6):442-6. PMID:11967568

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