2gs2
From Proteopedia
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[[Image:2gs2.png|left|200px]] | [[Image:2gs2.png|left|200px]] | ||
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{{STRUCTURE_2gs2| PDB=2gs2 | SCENE= }} | {{STRUCTURE_2gs2| PDB=2gs2 | SCENE= }} | ||
===Crystal Structure of the active EGFR kinase domain=== | ===Crystal Structure of the active EGFR kinase domain=== | ||
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{{ABSTRACT_PUBMED_16777603}} | {{ABSTRACT_PUBMED_16777603}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2gs2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GS2 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016777603</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Egfr]] | [[Category: Egfr]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
| - | + | [[Category: Transferase]] | |
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Revision as of 11:06, 7 January 2013
Crystal Structure of the active EGFR kinase domain
Template:ABSTRACT PUBMED 16777603
About this Structure
2gs2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell. 2006 Jun 16;125(6):1137-49. PMID:16777603 doi:10.1016/j.cell.2006.05.013
