1wce

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(New page: 200px<br /><applet load="1wce" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wce, resolution 7.0&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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'''CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION'''<br />
'''CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION'''<br />
==Overview==
==Overview==
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Double-stranded RNA virions are transcriptionally competent icosahedral, particles that must translocate across a lipid bilayer to function within, the cytoplasm of the target cell. Birnaviruses are unique among dsRNA, viruses as they have a single T = 13 icosahedral shell, lacking the, characteristic inner capsid observed in the others. We determined the, crystal structures of the T = 1 subviral particle (260 angstroms in, diameter) and of the T = 13 intact virus particle (700 angstroms in, diameter) of an avian birnavirus to 3 angstroms and 7 angstroms, resolution, respectively. Our results show that VP2, the only component of, the virus icosahedral capsid, is homologous both to the capsid protein of, positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13, capsid protein of members of the Reoviridae family of dsRNA viruses., Together, these results provide important insights into the multiple, functions of the birnavirus capsid and reveal unexpected structural, relationships among icosahedral viruses.
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Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm of the target cell. Birnaviruses are unique among dsRNA viruses as they have a single T = 13 icosahedral shell, lacking the characteristic inner capsid observed in the others. We determined the crystal structures of the T = 1 subviral particle (260 angstroms in diameter) and of the T = 13 intact virus particle (700 angstroms in diameter) of an avian birnavirus to 3 angstroms and 7 angstroms resolution, respectively. Our results show that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13 capsid protein of members of the Reoviridae family of dsRNA viruses. Together, these results provide important insights into the multiple functions of the birnavirus capsid and reveal unexpected structural relationships among icosahedral viruses.
==About this Structure==
==About this Structure==
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1WCE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Infectious_bursal_disease_virus Infectious bursal disease virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WCE OCA].
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1WCE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Infectious_bursal_disease_virus Infectious bursal disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCE OCA].
==Reference==
==Reference==
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[[Category: Navaza, J.]]
[[Category: Navaza, J.]]
[[Category: Pous, J.]]
[[Category: Pous, J.]]
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[[Category: Rey, F.A.]]
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[[Category: Rey, F A.]]
[[Category: birnavirus]]
[[Category: birnavirus]]
[[Category: double-stranded rna virus protein]]
[[Category: double-stranded rna virus protein]]
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[[Category: transcriptase machinery]]
[[Category: transcriptase machinery]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:18:21 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:42:45 2008''

Revision as of 13:42, 21 February 2008

Image:1wce.gif

1wce, resolution 7.0Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION

Overview

Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm of the target cell. Birnaviruses are unique among dsRNA viruses as they have a single T = 13 icosahedral shell, lacking the characteristic inner capsid observed in the others. We determined the crystal structures of the T = 1 subviral particle (260 angstroms in diameter) and of the T = 13 intact virus particle (700 angstroms in diameter) of an avian birnavirus to 3 angstroms and 7 angstroms resolution, respectively. Our results show that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13 capsid protein of members of the Reoviridae family of dsRNA viruses. Together, these results provide important insights into the multiple functions of the birnavirus capsid and reveal unexpected structural relationships among icosahedral viruses.

About this Structure

1WCE is a Single protein structure of sequence from Infectious bursal disease virus. Full crystallographic information is available from OCA.

Reference

The birnavirus crystal structure reveals structural relationships among icosahedral viruses., Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA, Cell. 2005 Mar 25;120(6):761-72. PMID:15797378

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