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1wq6
From Proteopedia
(New page: 200px<br /> <applet load="1wq6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wq6, resolution 2.00Å" /> '''The tetramer struct...) |
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| - | [[Image:1wq6.gif|left|200px]]<br /> | + | [[Image:1wq6.gif|left|200px]]<br /><applet load="1wq6" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1wq6" size=" | + | |
caption="1wq6, resolution 2.00Å" /> | caption="1wq6, resolution 2.00Å" /> | ||
'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br /> | '''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br /> | ||
==Overview== | ==Overview== | ||
| - | AML1/ETO is the chimeric protein resulting from the t(8;21) in acute | + | AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules. |
==About this Structure== | ==About this Structure== | ||
| - | 1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bushweller, J | + | [[Category: Bushweller, J H.]] |
| - | [[Category: Cheney, M | + | [[Category: Cheney, M D.]] |
[[Category: Chruszcz, M.]] | [[Category: Chruszcz, M.]] | ||
[[Category: Dauter, Z.]] | [[Category: Dauter, Z.]] | ||
| - | [[Category: Hartman, K | + | [[Category: Hartman, K L.]] |
| - | [[Category: Laue, T | + | [[Category: Laue, T M.]] |
[[Category: Liu, Y.]] | [[Category: Liu, Y.]] | ||
| - | [[Category: Lukasik, S | + | [[Category: Lukasik, S M.]] |
[[Category: Minor, W.]] | [[Category: Minor, W.]] | ||
| - | [[Category: Speck, N | + | [[Category: Speck, N A.]] |
[[Category: aml1-eto]] | [[Category: aml1-eto]] | ||
[[Category: eto]] | [[Category: eto]] | ||
[[Category: nhr2]] | [[Category: nhr2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:47:02 2008'' |
Revision as of 13:47, 21 February 2008
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The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity
Overview
AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.
About this Structure
1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331
Page seeded by OCA on Thu Feb 21 15:47:02 2008
Categories: Homo sapiens | Single protein | Bushweller, J H. | Cheney, M D. | Chruszcz, M. | Dauter, Z. | Hartman, K L. | Laue, T M. | Liu, Y. | Lukasik, S M. | Minor, W. | Speck, N A. | Aml1-eto | Eto | Nhr2
