1h1v

From Proteopedia

Revision as of 13:21, 30 October 2007

GELSOLIN G4-G6/ACTIN COMPLEX

Overview

Gelsolin participates in the reorganization of the actin cytoskeleton that, is required during such phenomena as cell movement, cytokinesis, and, apoptosis. It consists of six structurally similar domains, G1-G6, which, are arranged at resting intracellular levels of calcium ion so as to, obscure the three actin-binding surfaces. Elevation of Ca(2+), concentrations releases latches within the constrained structure and, produces large shifts in the relative positioning of the domains, permitting gelsolin to bind to and sever actin filaments. How Ca(2+) is, able to activate gelsolin has been a major question concerning the, function of this protein. We present the improved structure of the, C-terminal half of gelsolin bound to monomeric actin at 3.0 A resolution., Two classes of ... [(full description)]

About this Structure

1H1V is a [Protein complex] structure of sequences from [Homo sapiens] and [Oryctolagus cuniculus] with CA and ATP as [ligands]. This structure superseeds the now removed PDB entry 1DB0. Structure known Active Site: CA1. Full crystallographic information is available from [OCA].

Reference

The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex., Choe H, Burtnick LD, Mejillano M, Yin HL, Robinson RC, Choe S, J Mol Biol. 2002 Dec 6;324(4):691-702. PMID:12460571

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