1xnq
From Proteopedia
(New page: 200px<br /><applet load="1xnq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xnq, resolution 3.05Å" /> '''Structure of an Inos...) |
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| - | [[Image:1xnq.gif|left|200px]]<br /><applet load="1xnq" size=" | + | [[Image:1xnq.gif|left|200px]]<br /><applet load="1xnq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1xnq, resolution 3.05Å" /> | caption="1xnq, resolution 3.05Å" /> | ||
'''Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center'''<br /> | '''Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Here we report the crystal structures of I.C and I.A wobble base pairs in | + | Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position. |
==About this Structure== | ==About this Structure== | ||
| - | 1XNQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with PAR, MG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1XNQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=PAR:'>PAR</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| - | [[Category: Murphy, F | + | [[Category: Murphy, F V.]] |
[[Category: Ramakrishnan, V.]] | [[Category: Ramakrishnan, V.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: translation]] | [[Category: translation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:56:44 2008'' |
Revision as of 13:56, 21 February 2008
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Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center
Overview
Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.
About this Structure
1XNQ is a Protein complex structure of sequences from Thermus thermophilus with , and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of a purine-purine wobble base pair in the decoding center of the ribosome., Murphy FV 4th, Ramakrishnan V, Nat Struct Mol Biol. 2004 Dec;11(12):1251-2. Epub 2004 Nov 21. PMID:15558050
Page seeded by OCA on Thu Feb 21 15:56:44 2008
Categories: Protein complex | Thermus thermophilus | Murphy, F V. | Ramakrishnan, V. | MG | PAR | ZN | Decoding | Inosine | Ribosome | Translation
