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1h8f
From Proteopedia
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[[Category: kinase]] | [[Category: kinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:32:08 2007'' |
Revision as of 13:27, 30 October 2007
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GLYCOGEN SYNTHASE KINASE 3 BETA.
Overview
Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin, and Wnt signaling, phosphorylating downstream targets by default, and, becoming inhibited following the extracellular signaling event. The, crystal structure of human GSK3 beta shows a catalytically active, conformation in the absence of activation-segment phosphorylation, with, the sulphonate of a buffer molecule bridging the activation-segment and, N-terminal domain in the same way as the phosphate group of the, activation-segment phospho-Ser/Thr in other kinases. The location of this, oxyanion binding site in the substrate binding cleft indicates direct, coupling of P+4 phosphate-primed substrate binding and catalytic, activation, explains the ability of GSK3 beta to processively, hyperphosphorylate substrates ... [(full description)]
About this Structure
1H8F is a [Single protein] structure of sequence from [Homo sapiens] with EPE as [ligand]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition., Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH, Cell. 2001 Jun 15;105(6):721-32. PMID:11440715
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