1ypz
From Proteopedia
(New page: 200px<br /> <applet load="1ypz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ypz, resolution 3.40Å" /> '''Immune receptor'''<...) |
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| - | [[Image:1ypz.gif|left|200px]]<br /> | + | [[Image:1ypz.gif|left|200px]]<br /><applet load="1ypz" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ypz" size=" | + | |
caption="1ypz, resolution 3.40Å" /> | caption="1ypz, resolution 3.40Å" /> | ||
'''Immune receptor'''<br /> | '''Immune receptor'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the | + | Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YPZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1YPZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Adams, E | + | [[Category: Adams, E J.]] |
| - | [[Category: Garcia, K | + | [[Category: Garcia, K C.]] |
[[Category: beta-2-microglobulin]] | [[Category: beta-2-microglobulin]] | ||
[[Category: h2-t22 protein]] | [[Category: h2-t22 protein]] | ||
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[[Category: t-cell receptor gamma chain]] | [[Category: t-cell receptor gamma chain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:55 2008'' |
Revision as of 14:07, 21 February 2008
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Immune receptor
Contents |
Overview
Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1YPZ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22., Adams EJ, Chien YH, Garcia KC, Science. 2005 Apr 8;308(5719):227-31. PMID:15821084
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