Jms/sandbox8

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Current revision (12:23, 24 January 2013) (edit) (undo)
 
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== Your Heading Here (maybe something like 'Structure') ==
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== Prediction about Hsp12 with Gfp ==
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<StructureSection load='1dq8' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>
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<StructureSection load='2ljl' size='350' side='right' caption='Structure of Hsp12 (PDB entry [[1ljl]])' scene=''>
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Anything in this section will appear adjacent to the 3D structure and will be scrollable.
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The GFP likely does not interfere with the native function of Hsp12 because it is far from the localization tags while in the dynamic state in the cytoplasm. And in the membrane it is far from the helixes that actually stabalize the membrane.
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In independent studies Hsp12 was shown to form four helixes upon <scene name='Jms/sandbox8/Hsp12_membrane/1'>localization into the membrane of SDS micelles</scene>
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which was repeated <scene name='Jms/sandbox8/Hsp12_membrane_2/1'>with the same results</scene>
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however, in a dodecaphosphatidylcholine (DPC) micelle, it <scene name='Jms/sandbox8/Hsp12_unfolded/1'>only forms one helix</scene>
</StructureSection>
</StructureSection>
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<scene name='Jms/sandbox8/Hsp12_unfolded/1'>TextToBeDisplayed</scene>
 

Current revision

Prediction about Hsp12 with Gfp

Structure of Hsp12 (PDB entry 1ljl)

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Joseph M. Steinberger

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