Leukotriene A4 Hydrolase
From Proteopedia
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[[Image:2xpz.jpg|left|200px|thumb|Crystal Structure of Leukotriene A4 Hydrolase [[2xpz]]]] | [[Image:2xpz.jpg|left|200px|thumb|Crystal Structure of Leukotriene A4 Hydrolase [[2xpz]]]] | ||
{{STRUCTURE_2xpz| PDB=2xpz | SIZE=400| SCENE= |right|CAPTION=Leukotriene A4 Hydrolase complex with butanediol and PEG [[2xpz]] }} | {{STRUCTURE_2xpz| PDB=2xpz | SIZE=400| SCENE= |right|CAPTION=Leukotriene A4 Hydrolase complex with butanediol and PEG [[2xpz]] }} | ||
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Revision as of 13:25, 6 February 2013
Leukotriene A4 Hydrolase (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism. The images at the left and at the right correspond to one representative LTA4H, i.e. the crystal structure of yeast Leukotriene A4 Hydrolase (2xpz).
3D Structures of Leukotriene A4 Hydrolase
LTA4H
1xpy, 2xpz – yLTA4H – yeast
1sqm, 1gw6, 1h19 - hLTA4H (mutant) - human
LTA4H + inhibitor
2xq0 – yLTA4H+bestatin
3fh5, 3fh7, 3fh8, 3fhe, 3ful, 3fum, 3fun - hLTA4H+pyrrolidine inhibitor
1hs6 - hLTA4H+bestatin
3ftz, 3ftv, 3ftw, 3ftx, 3fui - hLTA4H+aniline derivative
3fts, 3ftu - hLTA4H+resveratrol derivative
3fty, 3fu0 - hLTA4H+pyridine derivative
3fu3, 3fu5, 3fu6, 3fud - hLTA4H+thio derivative
3fue, 3fuf, 3fuh - hLTA4H+bestatin+indole derivative
3fuj, 3fuk - hLTA4H+indole derivative
3b7r, 3cho, 3chp, 3chq, 3chr, 3chs, 2r59 - hLTA4H+inhibitor
3b7u - hLTA4H+kelatorphan
2vj8 - hLTA4H+hydroxamic acid
3b7s, 3b7t - hLTA4H (mutant)+tripeptide
