2a91
From Proteopedia
(New page: 200px<br /> <applet load="2a91" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a91, resolution 2.5Å" /> '''Crystal structure of...) |
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| - | [[Image:2a91.gif|left|200px]]<br /> | + | [[Image:2a91.gif|left|200px]]<br /><applet load="2a91" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2a91, resolution 2.5Å" /> | caption="2a91, resolution 2.5Å" /> | ||
'''Crystal structure of ErbB2 domains 1-3'''<br /> | '''Crystal structure of ErbB2 domains 1-3'''<br /> | ||
==Overview== | ==Overview== | ||
| - | ErbB2 does not bind ligand, yet appears to be the major signaling partner | + | ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2A91 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | + | 2A91 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A91 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
| - | [[Category: Adams, T | + | [[Category: Adams, T E.]] |
| - | [[Category: Burgess, A | + | [[Category: Burgess, A W.]] |
| - | [[Category: Elleman, T | + | [[Category: Elleman, T C.]] |
| - | [[Category: Garrett, T | + | [[Category: Garrett, T P.J.]] |
| - | [[Category: Jorissen, R | + | [[Category: Jorissen, R N.]] |
[[Category: Kofler, M.]] | [[Category: Kofler, M.]] | ||
[[Category: Lou, M.]] | [[Category: Lou, M.]] | ||
| - | [[Category: Lovrecz, G | + | [[Category: Lovrecz, G O.]] |
| - | [[Category: McKern, N | + | [[Category: McKern, N M.]] |
| - | [[Category: Nice, E | + | [[Category: Nice, E C.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: tyrosine kinase receptor; cell-surface receptor]] | [[Category: tyrosine kinase receptor; cell-surface receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:24:58 2008'' |
Revision as of 14:24, 21 February 2008
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Crystal structure of ErbB2 domains 1-3
Contents |
Overview
ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.
Disease
Known diseases associated with this structure: Adenocarcinoma of lung, somatic OMIM:[164870], Gastric cancer, somatic OMIM:[164870], Glioblastoma, somatic OMIM:[164870], Ovarian cancer, somatic, OMIM:[164870], Sialidosis, type I OMIM:[608272], Sialidosis, type II OMIM:[608272]
About this Structure
2A91 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors., Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW, Mol Cell. 2003 Feb;11(2):495-505. PMID:12620236
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