This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1kiv
From Proteopedia
| Line 21: | Line 21: | ||
[[Category: lysine binding site]] | [[Category: lysine binding site]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:41:15 2007'' |
Revision as of 13:36, 30 October 2007
|
RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)
Overview
The kringle modules of apolipoprotein(a) [apo(a)] of lipoprotein(a), [Lp(a)] are highly homologous with kringle 4 of plasminogen (75-94%) and, like the latter are autonomous structural and functional units. Apo(a), contains 14-37 kringle 4 (KIV) repeats distributed into 10 classes (1-10)., Lp(a) binds lysine-Sepharose via a lysine binding site (LBS) located in, KIV-10 (88% homology with plasminogen K4). However, the W72R substitution, that occurs in rhesus monkeys and occasionally in humans leads to impaired, lysine binding capacity of KIV-10 and Lp(a). The foregoing has been, investigated by determining the structures of KIV-10/M66 (M66 variant) in, its unliganded and ligand [epsilon-aminocaproic acid (EACA)] bound modes, and the structure of recombinant KIV-10/M66R72 (the W72R mutant). ... [(full description)]
About this Structure
1KIV is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Site: LBS. Full crystallographic information is available from [OCA].
Reference
Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance., Mochalkin I, Cheng B, Klezovitch O, Scanu AM, Tulinsky A, Biochemistry. 1999 Feb 16;38(7):1990-8. PMID:10026282
Page seeded by OCA on Tue Oct 30 15:41:15 2007
