Acetylcholine binding protein
From Proteopedia
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Revision as of 13:08, 6 March 2013
Acetylcholine binding protein (AChBP) is secreted by snails into cholinergic synapses, where it modulates transmission by binding acetylcholine (ACh). Sequence alignment revealed high similarity to the extracellular domains of the ligand-binding subunits of the nicotinic acetylcholine receptor (nAChR). The crystal structure of the AChBP homopentamer indeed provides a valuable model for identifying the nature of the ligand-binding domains and of the subunit interfaces of the nAChR. Furthermore, crystal structures of complexes of AChBP with various agonists and antagonists have provided detailed insight into the neurotransmitter binding site of nAChRs. The images on the left and right correspond to one representative AChBP structure, i.e. the Acetylcholine binding protein from Aplysia californica (2byn).
3D Structures of Acetylcholine binding protein
Updated on 06-March-2013
AChBP - Apo proteins
2w8e, 2byn, 2y7y - Aplysia californica (AcAChBP)
2xz6, 3sh1, 3sio, 3t4m – AcAChBP (mutant)
1ux2, 1i9b - Lymnaea stagnalis (LsAChBP)
2bj0 - Bulinus truncatus
AChBP + marine biotoxins
2wzy - AcAChBP + 13-desmethyl spirolide C
2x00 - AcAChBP + gymnodimine A
AChBP + partial agonists; Activate the receptor with partial efficacy
2wn9 - AcAChBP + 4-OH-DMXBA
2wnc - AcAChBP + tropisetron
2wnj - AcAChBP + DMXBA
2wnl - AcAChBP + anabaseine
AChBP+ions; Mimicking the ion conductance of the receptor
3gua - AcAChBP + sulfate
AChBP+ neonicotinoids; Insecticides with lower affinity to mammals
3c79 - AcAChBP + imidacloprid
2zju - LsAChBP + imidacloprid
3c84 - AcAChBP + thiacloprid
2zjv - LsAChBP+clothianidin
AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction
2pjz - AcAChBP+cocaine
2ph9 - AcAChBP+galanthamine
2w8f, 2w8g - AcAChBP + in silico compounds
AChBP+ peptide inhibitors
2c9t, 2byp, 2br8 - AcAChBP+conotoxin IMI
2uz6 – AcAChBP fragment + α-conotoxin
1yi5 - AcAChBP+cobratoxin
AChBP+ nicotinic agonists enhance the action of the nAChR
2pgz - AcAChBP+cocaine
2byr - AcAChBP+methyllycaconitine
2bys - AcAChBP+lobeline
2xnt, 2xnu, 2xnv – AcAChBP + ligand
3peo - AcAChBP+metocurine
3pmz - AcAChBP+tubocurarine
2byq - AcAChBP+epibatidine
AChBP+ ligand homologs of the ligand acetylcholine
1uv6 - LsAChBP+ carbamylcholine
1uw6 - LsAChBP+nicotine
2xz5 – AcAChBP (mutant) + acetylcholine
AChBP+others
2br7 - AcAChBP+ HEPES
2y54, 2y56, 2y57, 2y58 – AcAChBP residues 20-236 + azabicyclo-octan benzoate derivative
AChBP α-7
3sq6, 3sq9 – AchBP h/Ls chimera
Additional Resources
For additional information, see: Alzheimer's Disease
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, David Canner
