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Template:STRUCTURE 2hyy

From Proteopedia

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Current revision

2hyy, resolution 2.40Å ()

Ligands:

Gene:

ABL1 (Homo sapiens)

Activity:

Non-specific protein-tyrosine kinase, with EC number 2.7.10.2

Related:

1iep, 1fpu

Structural annotation:
Resources:	InterPro : Ipr015015, Ipr000980, Ipr000719, Ipr011009, Ipr001245, Ipr008266, Ipr001452 Pfam : PF07714 UniProt : P00519

Functional annotation:
Cellular component:	cytoplasm nucleus cytoskeleton
Biological process:	actin cytoskeleton organization and biogenesis protein amino acid phosphorylation peptidyl-tyrosine phosphorylation intracellular signaling cascade mismatch repair DNA damage response, signal transduction resulting in induction of apoptosis S-phase-specific transcription in mitotic cell cycle regulation of transcription, DNA-dependent cell adhesion protein modification process
Molecular function:	ATP binding transferase activity protein-tyrosine kinase activity protein C-terminus binding nucleotide binding manganese ion binding magnesium ion binding protein kinase activity kinase activity protein binding DNA binding metal ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_2hyy"

@@ Line 1: / Line 1: @@
-{{StructureD
+{{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|2hyy, resolution 2.40&Aring; (<scene name='initialview01'>initial scene</scene>)}}}
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[2hyy]], [[Resolution|resolution]] 2.40&Aring; (<scene name='initialview01'>default scene</scene>)}}}
 |LIGAND= <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>
 |GENE= ABL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00220 S_TKc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05052 PTKc_Abl]</span>
 |RELATEDENTRY=[[1iep|1iep]], [[1fpu|1fpu]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hyy OCA], [http://www.ebi.ac.uk/pdbsum/2hyy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hyy RCSB]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hyy RCSB], [http://www.ebi.ac.uk/pdbsum/2hyy PDBsum]</span>
 |FUNCTION={{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0004713 | text = protein-tyrosine kinase activity}}{{GO|id=GO:0008022 | text = protein C-terminus binding}}{{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0030145 | text = manganese ion binding}}{{GO|id=GO:0000287 | text = magnesium ion binding}}{{GO|id=GO:0004672 | text = protein kinase activity}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0003677 | text = DNA binding}}{{GO|id=GO:0046872 | text = metal ion binding}}
 |PROCESS={{GO|id=GO:0030036 | text = actin cytoskeleton organization and biogenesis}}{{GO|id=GO:0006468 | text = protein amino acid phosphorylation}}{{GO|id=GO:0018108 | text = peptidyl-tyrosine phosphorylation}}{{GO|id=GO:0007242 | text = intracellular signaling cascade}}{{GO|id=GO:0006298 | text = mismatch repair}}{{GO|id=GO:0008630 | text = DNA damage response, signal transduction resulting in induction of apoptosis}}{{GO|id=GO:0000115 | text = S-phase-specific transcription in mitotic cell cycle}}{{GO|id=GO:0006355 | text = regulation of transcription, DNA-dependent}}{{GO|id=GO:0007155 | text = cell adhesion}}{{GO|id=GO:0006464 | text = protein modification process}}
 |COMPONENT={{GO|id=GO:0005737 | text = cytoplasm}}{{GO|id=GO:0005634 | text = nucleus}}{{GO|id=GO:0005856 | text = cytoskeleton}}
 |SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR015015 Ipr015015], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000980 Ipr000980], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000719 Ipr000719], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011009 Ipr011009], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001245 Ipr001245], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR008266 Ipr008266], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001452 Ipr001452]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF07714 PF07714]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P00519 P00519]</span>
-|FARESOURCES=<span class='plainlinks'>GeneCard : [http://www.genecards.org/cgi-bin/carddisp.pl?id=ABL1 ABL1]</span>
+|uPDB=2HYY|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_2hyy_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>B [x]</text>
+<name>jmb_2hyy_B</name>
+<title>toggle chain B</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>C [x]</text>
+<name>jmb_2hyy_C</name>
+<title>toggle chain C</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>D [x]</text>
+<name>jmb_2hyy_D</name>
+<title>toggle chain D</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 2hyy

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