Growth factor receptor-bound protein
From Proteopedia
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<StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''> | <StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''> | ||
| - | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors. | + | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains |
==3D structures of Grb== | ==3D structures of Grb== | ||
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[[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]], [[1aze]] - GRB2 SH3 domain + SOS-1 peptide – NMR<br /> | [[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]], [[1aze]] - GRB2 SH3 domain + SOS-1 peptide – NMR<br /> | ||
[[1io6]], [[1h3h]] - GRB2 SH3 domain + ligand peptide – NMR | [[1io6]], [[1h3h]] - GRB2 SH3 domain + ligand peptide – NMR | ||
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| + | ===GRB7=== | ||
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| + | [[1mw4]], [[2l4k]] – hGRB7 SH2 domain + receptor protein-tyrosine kinase ERBB-2 SH2 binding site – human – NMR<br /> | ||
| + | [[2qms]] – hGRB7 SH2 domain <br /> | ||
| + | [[3pqz]] – hGRB7 SH2 domain + cyclic peptide<br /> | ||
| + | [[1wgr]] – hGRB7 RA domain – NMR<br /> | ||
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| + | ===GRB10=== | ||
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| + | [[3hk0]] – hGRB10 RA+PH domains <br /> | ||
| + | [[1nrv]] – hGRB10 SH2 domain <br /> | ||
| + | [[3m7f]] – hGRB10 SH2 domain + E3 ubiquitin-protein ligase NEDD4 C2 domain<br /> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:48, 18 March 2013
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