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13gs

From Proteopedia

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[[Image:13gs.png|left|200px]]
 
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{{STRUCTURE_13gs| PDB=13gs | SCENE= }}
{{STRUCTURE_13gs| PDB=13gs | SCENE= }}
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===GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE===
===GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE===
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{{ABSTRACT_PUBMED_10452896}}
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==Function==
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[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.]<ref>PMID:21668448</ref>
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{{ABSTRACT_PUBMED_10452896}}
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==About this Structure==
==About this Structure==
[[13gs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13GS OCA].
[[13gs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13GS OCA].
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==See Also==
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*[[Glutathione S-transferase|Glutathione S-transferase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:010452896</ref><references group="xtra"/>
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<ref group="xtra">PMID:010452896</ref><references group="xtra"/><references/>
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 10:26, 21 March 2013

Template:STRUCTURE 13gs

Contents

GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE

Template:ABSTRACT PUBMED 10452896

Function

[GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.][1]

About this Structure

13gs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Oakley AJ, Lo Bello M, Nuccetelli M, Mazzetti AP, Parker MW. The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site). J Mol Biol. 1999 Aug 27;291(4):913-26. PMID:10452896 doi:10.1006/jmbi.1999.3029
  1. ↑ Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub , 2011 Jul 8. PMID:21668448 doi:10.1111/j.1471-4159.2011.07343.x

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