1bht

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1bht" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1bht.png|left|200px]]
 
- 
{{STRUCTURE_1bht| PDB=1bht | SCENE= }}
{{STRUCTURE_1bht| PDB=1bht | SCENE= }}
- 
===NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR===
===NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR===
 +
{{ABSTRACT_PUBMED_9817840}}
-
{{ABSTRACT_PUBMED_9817840}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[http://omim.org/entry/608265 608265]]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref><ref>PMID:20624990</ref>
==About this Structure==
==About this Structure==
Line 11: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:009817840</ref><references group="xtra"/>
+
<ref group="xtra">PMID:009817840</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Godowski, P J.]]
[[Category: Godowski, P J.]]

Revision as of 08:57, 24 March 2013

Template:STRUCTURE 1bht

Contents

NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR

Template:ABSTRACT PUBMED 9817840

Disease

[HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.[1]

Function

[HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.[2][3]

About this Structure

1bht is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ultsch M, Lokker NA, Godowski PJ, de Vos AM. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution. Structure. 1998 Nov 15;6(11):1383-93. PMID:9817840
  1. ↑ Schultz JM, Khan SN, Ahmed ZM, Riazuddin S, Waryah AM, Chhatre D, Starost MF, Ploplis B, Buckley S, Velasquez D, Kabra M, Lee K, Hassan MJ, Ali G, Ansar M, Ghosh M, Wilcox ER, Ahmad W, Merlino G, Leal SM, Riazuddin S, Friedman TB, Morell RJ. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. Am J Hum Genet. 2009 Jul;85(1):25-39. doi: 10.1016/j.ajhg.2009.06.003. Epub 2009 , Jul 2. PMID:19576567 doi:10.1016/j.ajhg.2009.06.003
  2. ↑ Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J. 2004 Jun 16;23(12):2325-35. Epub 2004 May 27. PMID:15167892 doi:10.1038/sj.emboj.7600243
  3. ↑ Tolbert WD, Daugherty-Holtrop J, Gherardi E, Vande Woude G, Xu HE. Structural basis for agonism and antagonism of hepatocyte growth factor. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13264-9. Epub 2010 Jul 12. PMID:20624990 doi:10.1073/pnas.1005183107

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bht"
Personal tools