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2riw
From Proteopedia
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| - | [[Image:2riw.png|left|200px]] | ||
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{{STRUCTURE_2riw| PDB=2riw | SCENE= }} | {{STRUCTURE_2riw| PDB=2riw | SCENE= }} | ||
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===The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine=== | ===The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine=== | ||
| + | {{ABSTRACT_PUBMED_21325280}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021325280</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021325280</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Carrell, R W.]] | [[Category: Carrell, R W.]] | ||
Revision as of 09:51, 24 March 2013
Contents |
The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine
Template:ABSTRACT PUBMED 21325280
Disease
[THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.
Function
[THBG_HUMAN] Major thyroid hormone transport protein in serum.
About this Structure
2riw is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A. Allosteric modulation of hormone release from thyroxine and corticosteroid binding-globulins. J Biol Chem. 2011 Feb 16. PMID:21325280 doi:10.1074/jbc.M110.171082
