2dts
From Proteopedia
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{{STRUCTURE_2dts| PDB=2dts | SCENE= }} | {{STRUCTURE_2dts| PDB=2dts | SCENE= }} | ||
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===Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1=== | ===Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1=== | ||
| + | {{ABSTRACT_PUBMED_17368483}} | ||
| - | + | ==Disease== | |
| - | + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2dts]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DTS OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017368483</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kato, K.]] | [[Category: Kato, K.]] | ||
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[[Category: Defucosylated glycoform]] | [[Category: Defucosylated glycoform]] | ||
[[Category: Igg1]] | [[Category: Igg1]] | ||
| + | [[Category: Immune system]] | ||
[[Category: Immunoglobulin]] | [[Category: Immunoglobulin]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:40:49 2009'' | ||
Revision as of 10:08, 24 March 2013
Contents |
Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1
Template:ABSTRACT PUBMED 17368483
Disease
[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
About this Structure
2dts is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Matsumiya S, Yamaguchi Y, Saito J, Nagano M, Sasakawa H, Otaki S, Satoh M, Shitara K, Kato K. Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1. J Mol Biol. 2007 May 4;368(3):767-79. Epub 2007 Feb 22. PMID:17368483 doi:10.1016/j.jmb.2007.02.034
