This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1sac
From Proteopedia
m (Protected "1sac" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1sac.png|left|200px]] | ||
| - | |||
{{STRUCTURE_1sac| PDB=1sac | SCENE= }} | {{STRUCTURE_1sac| PDB=1sac | SCENE= }} | ||
| - | |||
===THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT=== | ===THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT=== | ||
| + | {{ABSTRACT_PUBMED_8114934}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. | ||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:008114934</ref><ref group="xtra">PMID:011170211</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/> | + | <ref group="xtra">PMID:008114934</ref><ref group="xtra">PMID:011170211</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Blundell, T L.]] | [[Category: Blundell, T L.]] | ||
Revision as of 11:21, 24 March 2013
Contents |
THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT
Template:ABSTRACT PUBMED 8114934
Disease
[SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
Function
[SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
About this Structure
1sac is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP. Structure of pentameric human serum amyloid P component. Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934 doi:http://dx.doi.org/10.1038/367338a0
- Thomas A, Bouffioux O, Geeurickx D, Brasseur R. Pex, analytical tools for PDB files. I. GF-Pex: basic file to describe a protein. Proteins. 2001 Apr 1;43(1):28-36. PMID:11170211
- Richardson JS, Richardson DC. Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2754-9. PMID:11880627 doi:10.1073/pnas.052706099
