2d9q
From Proteopedia
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{{STRUCTURE_2d9q| PDB=2d9q | SCENE= }} | {{STRUCTURE_2d9q| PDB=2d9q | SCENE= }} | ||
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===Crystal Structure of the Human GCSF-Receptor Signaling Complex=== | ===Crystal Structure of the Human GCSF-Receptor Signaling Complex=== | ||
| + | {{ABSTRACT_PUBMED_16492764}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Defects in CSF3R are the cause of hereditary neutrophilia (NEUTROPHILIA) [MIM:[http://omim.org/entry/162830 162830]]. A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.<ref>PMID:19620628</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [[http://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.<ref>PMID:7514305</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016492764</ref><ref group="xtra">PMID:014992583</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016492764</ref><ref group="xtra">PMID:014992583</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kuroki, R.]] | [[Category: Kuroki, R.]] | ||
Revision as of 17:39, 24 March 2013
Contents |
Crystal Structure of the Human GCSF-Receptor Signaling Complex
Template:ABSTRACT PUBMED 16492764
Disease
[CSF3R_HUMAN] Defects in CSF3R are the cause of hereditary neutrophilia (NEUTROPHILIA) [MIM:162830]. A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.[1]
Function
[CSF3_HUMAN] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [CSF3R_HUMAN] Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.[2]
About this Structure
2d9q is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R. Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3135-40. Epub 2006 Feb 21. PMID:16492764
- Mine S, Koshiba T, Honjo E, Okamoto T, Tamada T, Maeda Y, Matsukura Y, Horie A, Ishibashi M, Sato M, Azuma M, Tokunaga M, Nitta K, Kuroki R. Thermodynamic analysis of the activation mechanism of the GCSF receptor induced by ligand binding. Biochemistry. 2004 Mar 9;43(9):2458-64. PMID:14992583 doi:http://dx.doi.org/10.1021/bi0356855
- ↑ Plo I, Zhang Y, Le Couedic JP, Nakatake M, Boulet JM, Itaya M, Smith SO, Debili N, Constantinescu SN, Vainchenker W, Louache F, de Botton S. An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J Exp Med. 2009 Aug 3;206(8):1701-7. doi: 10.1084/jem.20090693. Epub 2009 Jul 20. PMID:19620628 doi:10.1084/jem.20090693
- ↑ Dong F, Hoefsloot LH, Schelen AM, Broeders CA, Meijer Y, Veerman AJ, Touw IP, Lowenberg B. Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4480-4. PMID:7514305
