1py2

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[[Image:1py2.png|left|200px]]
 
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{{STRUCTURE_1py2| PDB=1py2 | SCENE= }}
{{STRUCTURE_1py2| PDB=1py2 | SCENE= }}
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===Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2===
===Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2===
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{{ABSTRACT_PUBMED_14664558}}
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{{ABSTRACT_PUBMED_14664558}}
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==Disease==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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==Function==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:014664558</ref><references group="xtra"/>
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<ref group="xtra">PMID:014664558</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Randal, M.]]
[[Category: Randal, M.]]

Revision as of 17:39, 24 March 2013

Template:STRUCTURE 1py2

Contents

Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2

Template:ABSTRACT PUBMED 14664558

Disease

[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Function

[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

About this Structure

1py2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Thanos CD, Randal M, Wells JA. Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc. 2003 Dec 17;125(50):15280-1. PMID:14664558 doi:10.1021/ja0382617

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OCA

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