1odh
From Proteopedia
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
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Revision as of 13:45, 30 October 2007
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STRUCTURE OF THE GCM DOMAIN BOUND TO DNA
Overview
Glia cell missing (GCM) transcription factors form a small family of, transcriptional regulators in metazoans. The prototypical Drosophila GCM, protein directs the differentiation of neuron precursor cells into glia, cells, whereas mammalian GCM proteins are involved in placenta and, parathyroid development. GCM proteins share a highly conserved 150 amino, acid residue region responsible for DNA binding, known as the GCM domain., Here we present the crystal structure of the GCM domain from murine GCMa, bound to its octameric DNA target site at 2.85 A resolution. The GCM, domain exhibits a novel fold consisting of two domains tethered together, by one of two structural Zn ions. We observe the novel use of a beta-sheet, in DNA recognition, whereby a five- stranded beta-sheet protrudes into ... [(full description)]
About this Structure
1ODH is a [Protein complex] structure of sequences from [Mus musculus] with ZN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition., Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Muller CW, EMBO J. 2003 Apr 15;22(8):1835-45. PMID:12682016
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