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Template:STRUCTURE 1opl

From Proteopedia

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Current revision

1opl, resolution 3.42Å ()

Ligands:

Gene:

Abl (Homo sapiens)

Activity:

Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2

Related:

1opj, 1opk

Structural annotation:
Resources:	CATH : 1Opla04, 1Opla03, 1Opla02, 1Opla01 InterPro : Ipr011009, Ipr008266, Ipr015015, Ipr001245, Ipr000980, Ipr000719, Ipr001452 Pfam : PF07714, PF00018, PF00017 SCOP : d1opla3, d1opla2, d1opla1, d1oplb1, d1oplb2 UniProt : P00519

Functional annotation:
Cellular component:	cytoskeleton cytoplasm nucleus
Biological process:	protein amino acid phosphorylation DNA damage response, signal transduction resulting in induction of apoptosis intracellular signaling cascade S-phase-specific transcription in mitotic cell cycle cell adhesion actin cytoskeleton organization and biogenesis mismatch repair regulation of transcription, DNA-dependent peptidyl-tyrosine phosphorylation protein modification process
Molecular function:	transferase activity protein C-terminus binding nucleotide binding kinase activity metal ion binding manganese ion binding magnesium ion binding protein kinase activity ATP binding protein-tyrosine kinase activity DNA binding protein binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_1opl"

@@ Line 1: / Line 1: @@
 {{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE=350|CAPTION= 1opl, resolution 3.42&Aring; (<scene name='initialview01'>initial scene</scene>)
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1opl]], [[Resolution|resolution]] 3.42&Aring; (<scene name='initialview01'>default scene</scene>)}}}
-|SITE=
 |LIGAND= <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=P16:6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>P16</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
 |GENE= Abl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05052 PTKc_Abl], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00173 SH2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00220 S_TKc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00174 SH3]</span>
 |RELATEDENTRY=[[1opj|1opj]], [[1opk|1opk]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opl OCA], [http://www.ebi.ac.uk/pdbsum/1opl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1opl RCSB]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1opl RCSB], [http://www.ebi.ac.uk/pdbsum/1opl PDBsum]</span>
+|FUNCTION={{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0008022 | text = protein C-terminus binding}}{{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0046872 | text = metal ion binding}}{{GO|id=GO:0030145 | text = manganese ion binding}}{{GO|id=GO:0000287 | text = magnesium ion binding}}{{GO|id=GO:0004672 | text = protein kinase activity}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0004713 | text = protein-tyrosine kinase activity}}{{GO|id=GO:0003677 | text = DNA binding}}{{GO|id=GO:0005515 | text = protein binding}}
+|PROCESS={{GO|id=GO:0006468 | text = protein amino acid phosphorylation}}{{GO|id=GO:0008630 | text = DNA damage response, signal transduction resulting in induction of apoptosis}}{{GO|id=GO:0007242 | text = intracellular signaling cascade}}{{GO|id=GO:0000115 | text = S-phase-specific transcription in mitotic cell cycle}}{{GO|id=GO:0007155 | text = cell adhesion}}{{GO|id=GO:0030036 | text = actin cytoskeleton organization and biogenesis}}{{GO|id=GO:0006298 | text = mismatch repair}}{{GO|id=GO:0006355 | text = regulation of transcription, DNA-dependent}}{{GO|id=GO:0018108 | text = peptidyl-tyrosine phosphorylation}}{{GO|id=GO:0006464 | text = protein modification process}}
+|COMPONENT={{GO|id=GO:0005856 | text = cytoskeleton}}{{GO|id=GO:0005737 | text = cytoplasm}}{{GO|id=GO:0005634 | text = nucleus}}
+|SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1oplA04 1Opla04], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1oplA03 1Opla03], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1oplA02 1Opla02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1oplA01 1Opla01]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011009 Ipr011009], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR008266 Ipr008266], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR015015 Ipr015015], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001245 Ipr001245], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000980 Ipr000980], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000719 Ipr000719], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001452 Ipr001452]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF07714 PF07714], [http://pfam.sanger.ac.uk/family?acc=PF00018 PF00018], [http://pfam.sanger.ac.uk/family?acc=PF00017 PF00017]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=87237 d1opla3], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=87236 d1opla2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=87235 d1opla1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=87238 d1oplb1], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=87239 d1oplb2]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P00519 P00519]</span>
+|uPDB=1OPL|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_1opl_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>B [x]</text>
+<name>jmb_1opl_B</name>
+<title>toggle chain B</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 1opl

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