This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1p49

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1p49" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1p49.png|left|200px]]
 
- 
{{STRUCTURE_1p49| PDB=1p49 | SCENE= }}
{{STRUCTURE_1p49| PDB=1p49 | SCENE= }}
- 
===Structure of Human Placental Estrone/DHEA Sulfatase===
===Structure of Human Placental Estrone/DHEA Sulfatase===
 +
{{ABSTRACT_PUBMED_12657638}}
-
{{ABSTRACT_PUBMED_12657638}}
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/STS_HUMAN STS_HUMAN]] Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:[http://omim.org/entry/308100 308100]]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.<ref>PMID:1539590</ref><ref>PMID:9252398</ref><ref>PMID:10679952</ref><ref>PMID:10844566</ref>
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/STS_HUMAN STS_HUMAN]] Conversion of sulfated steroid precursors to estrogens during pregnancy.
==About this Structure==
==About this Structure==
Line 11: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:012657638</ref><references group="xtra"/>
+
<ref group="xtra">PMID:012657638</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Steryl-sulfatase]]
[[Category: Steryl-sulfatase]]

Revision as of 21:30, 24 March 2013

Template:STRUCTURE 1p49

Contents

Structure of Human Placental Estrone/DHEA Sulfatase

Template:ABSTRACT PUBMED 12657638

Disease

[STS_HUMAN] Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.[1][2][3][4]

Function

[STS_HUMAN] Conversion of sulfated steroid precursors to estrogens during pregnancy.

About this Structure

1p49 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hernandez-Guzman FG, Higashiyama T, Pangborn W, Osawa Y, Ghosh D. Structure of human estrone sulfatase suggests functional roles of membrane association. J Biol Chem. 2003 Jun 20;278(25):22989-97. Epub 2003 Mar 25. PMID:12657638 doi:10.1074/jbc.M211497200
  1. ↑ Basler E, Grompe M, Parenti G, Yates J, Ballabio A. Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. Am J Hum Genet. 1992 Mar;50(3):483-91. PMID:1539590
  2. ↑ Alperin ES, Shapiro LJ. Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. J Biol Chem. 1997 Aug 15;272(33):20756-63. PMID:9252398
  3. ↑ Sugawara T, Shimizu H, Hoshi N, Fujimoto Y, Nakajima A, Fujimoto S. PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. Hum Mutat. 2000 Mar;15(3):296. PMID:10679952 doi:<296::AID-HUMU17>3.0.CO;2-# 10.1002/(SICI)1098-1004(200003)15:3<296::AID-HUMU17>3.0.CO;2-#
  4. ↑ Oyama N, Satoh M, Iwatsuki K, Kaneko F. Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. J Invest Dermatol. 2000 Jun;114(6):1195-9. PMID:10844566 doi:jid004

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p49"
Personal tools