2exg
From Proteopedia
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| - | [[Image:2exg.png|left|200px]] | ||
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{{STRUCTURE_2exg| PDB=2exg | SCENE= }} | {{STRUCTURE_2exg| PDB=2exg | SCENE= }} | ||
| + | ===Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain=== | ||
| - | === | + | ==Disease== |
| + | [[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016671149</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016671149</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boisguerin, P.]] | [[Category: Boisguerin, P.]] | ||
Revision as of 22:06, 24 March 2013
Contents |
Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain
Disease
[AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
Function
[AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
About this Structure
2exg is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Joshi M, Vargas C, Boisguerin P, Diehl A, Krause G, Schmieder P, Moelling K, Hagen V, Schade M, Oschkinat H. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3790-5. PMID:16671149 doi:10.1002/anie.200503965
