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3e4u

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[[Image:3e4u.png|left|200px]]
 
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{{STRUCTURE_3e4u| PDB=3e4u | SCENE= }}
{{STRUCTURE_3e4u| PDB=3e4u | SCENE= }}
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===Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain===
===Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain===
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{{ABSTRACT_PUBMED_19052359}}
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==Disease==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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==Function==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref><ref>PMID:18280243</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 19052359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19052359}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019052359</ref><references group="xtra"/>
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<ref group="xtra">PMID:019052359</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Carr, S B.]]
[[Category: Carr, S B.]]

Revision as of 22:19, 24 March 2013

Template:STRUCTURE 3e4u

Contents

Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain

Template:ABSTRACT PUBMED 19052359

Disease

[BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Function

[BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.[1][2]

About this Structure

3e4u is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Stead MA, Rosbrook GO, Hadden JM, Trinh CH, Carr SB, Wright SC. Structure of the wild-type human BCL6 POZ domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1101-4., Epub 2008 Nov 28. PMID:19052359 doi:10.1107/S1744309108036063
  1. ↑ Niu H, Ye BH, Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 1998 Jul 1;12(13):1953-61. PMID:9649500
  2. ↑ Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243 doi:10.1016/j.molcel.2007.12.026

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