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Template:STRUCTURE 1v4s

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Current revision

1v4s, resolution 2.30Å ()

Ligands:

, ,

Activity:

Hexokinase, with EC number 2.7.1.1

Related:

1v4t

Structural annotation:
Resources:	InterPro : Ipr001312 Pfam : PF00349, PF03727 SCOP : d1v4sa2, d1v4sa1 UniProt : P35557

Functional annotation:
Biological process:	glucose homeostasis detection of glucose positive regulation of glycogen biosynthetic process glucose metabolic process glycolysis negative regulation of gluconeogenesis positive regulation of insulin secretion
Molecular function:	glucokinase activity kinase activity nucleotide binding hexokinase activity transferase activity ATP binding protein binding glucose binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_1v4s"

@@ Line 1: / Line 1: @@
-{{StructureD
+{{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|1v4s, resolution 2.30&Aring; (<scene name='initialview01'>initial scene</scene>)}}}
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1v4s]], [[Resolution|resolution]] 2.30&Aring; (<scene name='initialview01'>default scene</scene>)}}}
-|LIGAND= <scene name='pdbligand=GLC:SUGAR+(ALPHA-D-GLUCOSE)'>GLC</scene>, <scene name='pdbligand=MRK:2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE'>MRK</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+|LIGAND= <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MRK:2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE'>MRK</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00349 Hexokinase_1], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03727 Hexokinase_2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5026 COG5026]</span>
 |RELATEDENTRY=[[1v4t|1v4t]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4s OCA], [http://www.ebi.ac.uk/pdbsum/1v4s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v4s RCSB]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v4s RCSB], [http://www.ebi.ac.uk/pdbsum/1v4s PDBsum]</span>
 |FUNCTION={{GO|id=GO:0004340 | text = glucokinase activity}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0004396 | text = hexokinase activity}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0005536 | text = glucose binding}}
 |PROCESS={{GO|id=GO:0042593 | text = glucose homeostasis}}{{GO|id=GO:0051594 | text = detection of glucose}}{{GO|id=GO:0045725 | text = positive regulation of glycogen biosynthetic process}}{{GO|id=GO:0006006 | text = glucose metabolic process}}{{GO|id=GO:0006096 | text = glycolysis}}{{GO|id=GO:0045721 | text = negative regulation of gluconeogenesis}}{{GO|id=GO:0032024 | text = positive regulation of insulin secretion}}
 |SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001312 Ipr001312]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00349 PF00349], [http://pfam.sanger.ac.uk/family?acc=PF03727 PF03727]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=100310 d1v4sa2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=100309 d1v4sa1]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P35557 P35557]</span>
-|FARESOURCES=<span class='plainlinks'>GeneCard : [http://www.genecards.org/cgi-bin/carddisp.pl?id=GCK GCK]</span>
+|uPDB=1V4S|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_1v4s_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 1v4s

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