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1txd

From Proteopedia

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[[Image:1txd.png|left|200px]]
 
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{{STRUCTURE_1txd| PDB=1txd | SCENE= }}
{{STRUCTURE_1txd| PDB=1txd | SCENE= }}
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===Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF===
===Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF===
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{{ABSTRACT_PUBMED_15331592}}
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{{ABSTRACT_PUBMED_15331592}}
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==Disease==
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[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.
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==Function==
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[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015331592</ref><references group="xtra"/>
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<ref group="xtra">PMID:015331592</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gao, G.]]
[[Category: Gao, G.]]

Revision as of 05:20, 25 March 2013

Template:STRUCTURE 1txd

Contents

Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF

Template:ABSTRACT PUBMED 15331592

Disease

[ARHGC_HUMAN] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.

Function

[ARHGC_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.[1]

About this Structure

1txd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kristelly R, Gao G, Tesmer JJ. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25. PMID:15331592 doi:http://dx.doi.org/10.1074/jbc.M406056200
  1. ↑ Fukuhara S, Chikumi H, Gutkind JS. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. FEBS Lett. 2000 Nov 24;485(2-3):183-8. PMID:11094164

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OCA

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