This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3ncl
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3ncl.jpg|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3ncl", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3ncl| PDB=3ncl | SCENE= }} | {{STRUCTURE_3ncl| PDB=3ncl | SCENE= }} | ||
| - | |||
===Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor=== | ===Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_21276938}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | |
| - | + | ||
| - | + | ||
| - | + | ||
==About this Structure== | ==About this Structure== | ||
| Line 22: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021276938</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Matriptase]] | [[Category: Matriptase]] | ||
| Line 28: | Line 19: | ||
[[Category: Egea, P.]] | [[Category: Egea, P.]] | ||
[[Category: Ray, M.]] | [[Category: Ray, M.]] | ||
| + | [[Category: Benzamidine]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Phosphonate]] | ||
| + | [[Category: Proteinase-inhibitor complex]] | ||
| + | [[Category: Serine endopeptidase]] | ||
| + | [[Category: Serine proteinase]] | ||
Revision as of 06:07, 25 March 2013
Contents |
Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor
Template:ABSTRACT PUBMED 21276938
Disease
[ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.[1]
Function
[ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
About this Structure
3ncl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS. Peptide length and leaving-group sterics influence potency of Peptide phosphonate protease inhibitors. Chem Biol. 2011 Jan 28;18(1):48-57. PMID:21276938 doi:10.1016/j.chembiol.2010.11.007
- ↑ Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet. 2007 Mar;80(3):467-77. Epub 2007 Jan 23. PMID:17273967 doi:S0002-9297(07)60095-0
