1t2m
From Proteopedia
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| - | [[Image:1t2m.png|left|200px]] | ||
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{{STRUCTURE_1t2m| PDB=1t2m | SCENE= }} | {{STRUCTURE_1t2m| PDB=1t2m | SCENE= }} | ||
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===Solution Structure Of The Pdz Domain Of AF-6=== | ===Solution Structure Of The Pdz Domain Of AF-6=== | ||
| + | {{ABSTRACT_PUBMED_15684424}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015684424</ref><references group="xtra"/> | + | <ref group="xtra">PMID:015684424</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Huang, A D.]] | [[Category: Huang, A D.]] | ||
Revision as of 06:08, 25 March 2013
Contents |
Solution Structure Of The Pdz Domain Of AF-6
Template:ABSTRACT PUBMED 15684424
Disease
[AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
Function
[AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
About this Structure
1t2m is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Zhou H, Xu Y, Yang Y, Huang A, Wu J, Shi Y. Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr. J Biol Chem. 2005 Apr 8;280(14):13841-7. Epub 2005 Jan 31. PMID:15684424 doi:10.1074/jbc.M411065200
