This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4iul

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4iul| PDB=4iul | SCENE= }}
 +
===MIF4G domain of DAP5===
 +
{{ABSTRACT_PUBMED_23478064}}
-
The entry 4iul is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/IF4G2_HUMAN IF4G2_HUMAN]] Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.<ref>PMID:9049310</ref><ref>PMID:9032289</ref><ref>PMID:11511540</ref><ref>PMID:11943866</ref>
-
Authors: Frank, F., Virgili, G., Feoktistova, K., Sawicki, M., Sonenberg, N., Fraser, C., Nagar, B.
+
==About this Structure==
 +
[[4iul]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUL OCA].
-
Description: MIF4G domain of DAP5
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Feoktistova, K.]]
 +
[[Category: Frank, F.]]
 +
[[Category: Fraser, C.]]
 +
[[Category: Nagar, B.]]
 +
[[Category: Sawicki, M.]]
 +
[[Category: Sonenberg, N.]]
 +
[[Category: Virgili, G.]]
 +
[[Category: Eif4a]]
 +
[[Category: Heat repeat]]
 +
[[Category: Protein-protein interaction]]
 +
[[Category: Translation]]

Revision as of 08:40, 27 March 2013

Template:STRUCTURE 4iul

Contents

MIF4G domain of DAP5

Template:ABSTRACT PUBMED 23478064

Function

[IF4G2_HUMAN] Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.[1][2][3][4]

About this Structure

4iul is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Imataka H, Olsen HS, Sonenberg N. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 1997 Feb 17;16(4):817-25. PMID:9049310 doi:10.1093/emboj/16.4.817
  2. ↑ Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol Cell Biol. 1997 Mar;17(3):1615-25. PMID:9032289
  3. ↑ Pyronnet S, Dostie J, Sonenberg N. Suppression of cap-dependent translation in mitosis. Genes Dev. 2001 Aug 15;15(16):2083-93. PMID:11511540 doi:10.1101/gad.889201
  4. ↑ Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G, Kimchi A. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5400-5. Epub 2002 Apr 9. PMID:11943866 doi:10.1073/pnas.082102499

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4iul"
Personal tools