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4e2v

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'''Unreleased structure'''
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{{STRUCTURE_4e2v| PDB=4e2v | SCENE= }}
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===tRNA-guanine transglycosylase Y106F, C158V mutant in complex with preQ1===
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The entry 4e2v is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
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Authors: Schmidt, I., Reuter, K., Klebe, G., Heine, A., Tidten, N.
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==About this Structure==
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[[4e2v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2V OCA].
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Description: tRNA-guanine transglycosylase Y106F, C158V mutant in complex with preQ1
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[[Category: Zymomonas mobilis]]
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[[Category: Heine, A.]]
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[[Category: Klebe, G.]]
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[[Category: Reuter, K.]]
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[[Category: Schmidt, I.]]
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[[Category: Tidten, N.]]
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[[Category: Bacterial tgt]]
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[[Category: Guanin]]
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[[Category: Guanine exchange enzyme]]
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[[Category: Preq1]]
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[[Category: Substrate specificity]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trna]]

Revision as of 08:57, 27 March 2013

Template:STRUCTURE 4e2v

tRNA-guanine transglycosylase Y106F, C158V mutant in complex with preQ1

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

About this Structure

4e2v is a 1 chain structure with sequence from Zymomonas mobilis. Full crystallographic information is available from OCA.

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OCA

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