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3jv3
From Proteopedia
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{{STRUCTURE_3jv3| PDB=3jv3 | SCENE= }} | {{STRUCTURE_3jv3| PDB=3jv3 | SCENE= }} | ||
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===Structure of SH3E-DH unit of murine intersectin-1L=== | ===Structure of SH3E-DH unit of murine intersectin-1L=== | ||
| + | {{ABSTRACT_PUBMED_20585582}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ITSN1_MOUSE ITSN1_MOUSE]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1. | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV3 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020585582</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Ahmad, K F.]] | [[Category: Ahmad, K F.]] | ||
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[[Category: Synapse]] | [[Category: Synapse]] | ||
[[Category: Synaptosome]] | [[Category: Synaptosome]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:19:02 2010'' | ||
Revision as of 09:15, 27 March 2013
Contents |
Structure of SH3E-DH unit of murine intersectin-1L
Template:ABSTRACT PUBMED 20585582
Function
[ITSN1_MOUSE] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1.
About this Structure
3jv3 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Ahmad KF, Lim WA. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One. 2010 Jun 24;5(6):e11291. PMID:20585582 doi:10.1371/journal.pone.0011291
