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3kku

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Template:STRUCTURE 3kku

Contents

Cruzain in complex with a non-covalent ligand

Template:ABSTRACT PUBMED 20540517

Function

[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.

About this Structure

3kku is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  • Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905. PMID:20540517 doi:10.1021/jm100488w

Proteopedia Page Contributors and Editors (what is this?)

OCA

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