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3l2a

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[[Image:3l2a.png|left|200px]]
 
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{{STRUCTURE_3l2a| PDB=3l2a | SCENE= }}
{{STRUCTURE_3l2a| PDB=3l2a | SCENE= }}
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===Crystal structure of Reston Ebola VP35 interferon inhibitory domain===
===Crystal structure of Reston Ebola VP35 interferon inhibitory domain===
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{{ABSTRACT_PUBMED_20399790}}
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==Function==
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[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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{{ABSTRACT_PUBMED_20399790}}
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==About this Structure==
==About this Structure==
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3L2A is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2A OCA].
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[[3l2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2A OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20399790</ref><references group="xtra"/>
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<ref group="xtra">PMID:020399790</ref><references group="xtra"/><references/>
[[Category: Reston ebolavirus]]
[[Category: Reston ebolavirus]]
[[Category: Amarasinghe, G K.]]
[[Category: Amarasinghe, G K.]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Virion]]
[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:03:44 2010''
 

Revision as of 20:02, 4 April 2013

Template:STRUCTURE 3l2a

Contents

Crystal structure of Reston Ebola VP35 interferon inhibitory domain

Template:ABSTRACT PUBMED 20399790

Function

[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

About this Structure

3l2a is a 1 chain structure with sequence from Reston ebolavirus. Full crystallographic information is available from OCA.

Reference

  • Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Muhlberger E, Basler CF, Amarasinghe GK. Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain. J Mol Biol. 2010 Jun 11;399(3):347-57. Epub 2010 Apr 24. PMID:20399790 doi:10.1016/j.jmb.2010.04.022

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