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1okr

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[[Category: winged helix protein]]
[[Category: winged helix protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:27 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:57:23 2007''

Revision as of 13:52, 30 October 2007

Image:1okr.gif

1okr, resolution 2.40Å

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THREE-DIMENSIONAL STRUCTURE OF S.AUREUS METHICILLIN-RESISTANCE REGULATING TRANSCRIPTIONAL REPRESSOR MECI.

Overview

Methicillin-resistant Staphylococcus aureus is the main cause of, nosocomial and community-onset infections that affect millions of people, worldwide. Some methicillin-resistant Staphylococcus aureus infections, have become essentially untreatable by beta-lactams because of acquired, molecular machineries enabling antibiotic resistance. Evasion from, methicillin challenge is mainly achieved by the synthesis of a, penicillin-binding protein of low affinity for antibiotics, MecA, that, replaces regular penicillin-binding proteins in cell wall turnover when, these have been inactivated by antibiotics. MecA synthesis is regulated by, a signal transduction system consisting of the sensor/transducer MecR1 and, the 14-kDa transcriptional repressor MecI (also known as methicillin, repressor) that ... [(full description)]

About this Structure

1OKR is a [Single protein] structure of sequence from [Staphylococcus aureus] with CL and GOL as [ligands]. Structure known Active Site: AC2. Full crystallographic information is available from [OCA].

Reference

Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance., Garcia-Castellanos R, Marrero A, Mallorqui-Fernandez G, Potempa J, Coll M, Gomis-Ruth FX, J Biol Chem. 2003 Oct 10;278(41):39897-905. Epub 2003 Jul 24. PMID:12881514

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