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3lf0

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[[Image:3lf0.png|left|200px]]
 
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{{STRUCTURE_3lf0| PDB=3lf0 | SCENE= }}
{{STRUCTURE_3lf0| PDB=3lf0 | SCENE= }}
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===Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein===
===Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein===
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{{ABSTRACT_PUBMED_20521335}}
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==Function==
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[[http://www.uniprot.org/uniprot/GLNB_MYCTU GLNB_MYCTU]] In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).
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{{ABSTRACT_PUBMED_20521335}}
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==About this Structure==
==About this Structure==
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3LF0 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LF0 OCA].
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[[3lf0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LF0 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20521335</ref><references group="xtra"/>
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<ref group="xtra">PMID:020521335</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Owen, J L.]]
[[Category: Owen, J L.]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:09:21 2010''
 

Revision as of 20:35, 4 April 2013

Template:STRUCTURE 3lf0

Contents

Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein

Template:ABSTRACT PUBMED 20521335

Function

[GLNB_MYCTU] In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).

About this Structure

3lf0 is a 3 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Shetty ND, Reddy MC, Palaninathan SK, Owen JL, Sacchettini JC. Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Sci. 2010 Aug;19(8):1513-24. PMID:20521335 doi:10.1002/pro.430

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