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3ks8

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{{STRUCTURE_3ks8| PDB=3ks8 | SCENE= }}
{{STRUCTURE_3ks8| PDB=3ks8 | SCENE= }}
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===Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA===
===Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA===
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{{ABSTRACT_PUBMED_20018665}}
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==Function==
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[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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{{ABSTRACT_PUBMED_20018665}}
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==About this Structure==
==About this Structure==
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3KS8 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS8 OCA].
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[[3ks8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS8 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20018665</ref><references group="xtra"/>
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<ref group="xtra">PMID:020018665</ref><references group="xtra"/><references/>
[[Category: Reston ebolavirus]]
[[Category: Reston ebolavirus]]
[[Category: Bornholdt, Z A.]]
[[Category: Bornholdt, Z A.]]
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[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
[[Category: Transcription]]
[[Category: Transcription]]
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[[Category: Viral protein-rna complex]]
[[Category: Virion]]
[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:04:16 2010''
 

Revision as of 20:41, 4 April 2013

Template:STRUCTURE 3ks8

Contents

Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA

Template:ABSTRACT PUBMED 20018665

Function

[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

About this Structure

3ks8 is a 6 chain structure with sequence from Reston ebolavirus. Full crystallographic information is available from OCA.

Reference

  • Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, Macrae IJ, Saphire EO. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A. 2009 Dec 14. PMID:20018665

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