This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3l6c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3l6c.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3l6c", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3l6c| PDB=3l6c | SCENE= }}
{{STRUCTURE_3l6c| PDB=3l6c | SCENE= }}
- 
===X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor===
===X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor===
 +
{{ABSTRACT_PUBMED_20106978}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/SRR_RAT SRR_RAT]] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:16713567</ref> <ref>PMID:20106978</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20106978}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20106978 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20106978}}
+
==About this Structure==
==About this Structure==
-
3L6C is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6C OCA].
+
[[3l6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6C OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:20106978</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020106978</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
Line 40: Line 27:
[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:38:16 2010''
 

Revision as of 20:50, 4 April 2013

Template:STRUCTURE 3l6c

Contents

X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor

Template:ABSTRACT PUBMED 20106978

Function

[SRR_RAT] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.[1] [2]

About this Structure

3l6c is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
  1. ↑ Panatier A, Theodosis DT, Mothet JP, Touquet B, Pollegioni L, Poulain DA, Oliet SH. Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell. 2006 May 19;125(4):775-84. PMID:16713567 doi:10.1016/j.cell.2006.02.051
  2. ↑ Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3l6c"
Personal tools